NCGC Kinome Viewer
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Kinases are an important class of enzymes that are therapeutically relevant for a wide range of indications such as cancer and neurodegenerative diseases.
Given that there are roughly 500 different kinase proteins, selectivity—???and in some cases polypharmacology—is perhaps one of the most important parameters used during lead optimization.
Here the lead compound is subjected to a panel of kinase assays and the results are often projected onto the kinome dendrogram. Such visualizations provide an effective means to evaluate the selectivity profile of lead compounds.
At the moment the tool assumes that kinase activities are expressed in µM. Although being able to robustly project data onto the kinome dendrogram is an important step in evaluating selectivity, a more useful scenario is to consider the underlying kinase profile in a broader context of known/published results
NCGC Kinome Viewer is built as an accessible Java-based application for viewing kinases.
Free download from Shareware Connection - Kinases are an important class of enzymes that are therapeutically relevant for a wide range of indications such as cancer and neurodegenerative diseases.
Version: New | Platform: WinOther
Released Date: | Rating: 0 | Title: NCGC Kinome Viewer
Author Url: http://nih.gov
Program Info Url: http://nih.gov
Download Url: http://tripod.nih.gov/ws/kinome/kinome.jnlp
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