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EDISA for Windows

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EDISA (Extended Dimension Iterative Signature Algorithm) is a novel probabilistic clustering approach for 3D gene-condition-time datasets. Based on mathematical definitions of gene expression modules, the EDISA samples initial modules from the dataset which are then refined by removing genes and conditions until they comply with the module definition. A subsequent extension step ensures gene and condition maximality. We applied the algorithm to a synthetic dataset and were able to successfully recover the implanted modules over a range of background noise intensities. Analysis of microarray datasets has lead us to define three biologically relevant module types: 1) We found modules with independent response profiles to be the most prevalent ones. These modules comprise genes which are co-regulated under several conditions, yet with a different response pattern under each condition. 2) Coherent modules with similar responses under all conditions occurred frequently, too, and were often contained within these modules. 3) A third module type, which covers a response specific to a single condition was also detected, but rarely. All of these modules are essentially different types of biclusters.

Free download from Shareware Connection - EDISA (Extended Dimension Iterative Signature Algorithm) is a novel probabilistic clustering approach for 3D gene-condition-time datasets.

Publisher: ra.cs.uni-tuebingen.de | License: Shareware
Version: 1.0 | Size: 12687 KB | Platform: WinOther
Released Date: | Rating: 0 | Title: EDISA for Windows

Author Url: http://www.ra.cs.uni-tuebingen.de
Program Info Url: http://www.ra.cs.uni-tuebingen.de
Download Url: http://www.ra.cs.uni-tuebingen.de/software/EDISA/downloads/EDISA.zip

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