Breakage fusion bridge cycle simulator
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BFBsimulator simulates the structural and copy number consequences of breakage fusion bridge (BFB) cycles in silico.
Hundreds of aCGH profiles of many different tumour types are now freely available and many of these newly surveyed genomes contain amplified oncogenes. The most commonly cited explanation for the processes underlying gene amplification is the the repeated fusion and breakage of chromosomes following the loss of a telomere. However, this proposition has never been fully investigated. Using BFBsimulator, we can ask: i) Can the complex patterns of amplification within cancer genomes really be generated by BFB cycles? ii) What visible effect might BFB cycles have on tumour copy number profiles? iii) Is there a specific copy number a€?signaturea€™ of evolution though breakage fusion bridge cycles? iv) What is the prevalence of BFB cycling across different cancers?
Breakage fusion bridge cycle simulator License - Academic Free License (AFL)
Free download from Shareware Connection - BFBsimulator simulates the structural and copy number consequences of breakage fusion bridge (BFB) cycles in silico.
Version: 1.0 | Platform: WinOther
Released Date: | Rating: 0 | Title: Breakage fusion bridge cycle simulator
Author Url: http://sourceforge.net/projects/bfbsimulator
Program Info Url: http://sourceforge.net/projects/bfbsimulator
Download Url: http://sourceforge.net/projects/bfbsimulator
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